Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation

WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription; however, its role in bladder cancer remains largely unknown. Our study investigated the role of WDR5 in bladder cancer and demonstrated that WDR5 was upregulated...

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Publicat a:Sci Rep
Autors principals: Chen, Xu, Xie, Weibin, Gu, Peng, Cai, Qingqing, Wang, Bo, Xie, Yun, Dong, Wen, He, Wang, Zhong, Guangzheng, Lin, Tianxin, Huang, Jian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319178/
https://ncbi.nlm.nih.gov/pubmed/25656485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08293
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