Both Rare and Common Variants in PCSK9 Influence Plasma Low-Density Lipoprotein Cholesterol Level in American Indians

CONTEXT: Elevated LDL cholesterol (LDL-C) is an important risk factor for atherosclerosis and cardiovascular disease. Variants in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene have been associated not only with plasma LDL-C concentration, but also with ischemic heart disease. Little...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Tsai, Ching-Wei, North, Kari E., Tin, Adrienne, Haack, Karin, Franceschini, Nora, Saroja Voruganti, V., Laston, Sandy, Zhang, Ying, Best, Lyle G., MacCluer, Jean W., Beaty, Terri H., Navas-Acien, Ana, Kao, W. H. Linda, Howard, Barbara V.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318886/
https://ncbi.nlm.nih.gov/pubmed/25412415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-3340
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