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Top-Down 193-nm Ultraviolet Photodissociation Mass Spectrometry for Simultaneous Determination of Polyubiquitin Chain Length and Topology

[Image: see text] Protein ubiquitin modifications present a vexing analytical challenge, because of the dynamic changes in the site of modification on the substrate, the number of ubiquitin moieties attached, and the diversity of linkage patterns in which they are attached. Presented here is a metho...

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Publicat a:Anal Chem
Autors principals: Cannon, Joe R., Martinez-Fonts, Kirby, Robotham, Scott A., Matouschek, Andreas, Brodbelt, Jennifer S.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318624/
https://ncbi.nlm.nih.gov/pubmed/25559986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac5038363
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