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beta-Endorphin: development of tolerance and its reversal by 5-hydroxytryptophan in cats.

Tolerance to beta-endorphin developed acutely in cats if the administration of the peptide was repeated within the first 24 hr. The tolerance was reversed immediately by systemic administration of the serotonin precursor, 5-hydroxytryptophan. It was further shown that 5-hydroxytryptophan potentiates...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Hosobuchi, Y, Meglio, M, Adams, J E, Li, C H
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1977
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431825/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/302946/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.9.4017
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