The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

BACKGROUND: Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone modifications can result in dysregulation of cell growth, leading to neoplastic transformation and cell death. Renal tumors ha...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Park, Ki Cheong, Heo, Jun Hyeok, Jeon, Jeong Yong, Choi, Hye Ji, Jo, A Ra, Kim, Seung Won, Kwon, Ho Jeong, Hong, Sung Joon, Han, Kyung Seok
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318161/
https://ncbi.nlm.nih.gov/pubmed/25613585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-014-1003-1
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