Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

BACKGROUND: PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation....

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Bond, Catherine E, Bettington, Mark L, Pearson, Sally-Ann, McKeone, Diane M, Leggett, Barbara A, Whitehall, Vicki LJ
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318154/
https://ncbi.nlm.nih.gov/pubmed/25613750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1011-9
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