Loss of B-cell translocation gene 2 expression in estrogen receptor-positive breast cancer predicts tamoxifen resistance

B-cell translocation gene 2 (BTG2), a gene suppressed in a subset of aggressive breast cancer, is repressed by estrogen. BTG2 inhibits the expression of HER ligands and promotes AKT activation, which plays an essential role in the tamoxifen resistance of estrogen receptor (ER)-positive breast cancer...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Takahashi, Maiko, Hayashida, Tetsu, Okazaki, Hiroshi, Miyao, Kazuhiro, Jinno, Hiromitsu, Kitagawa, Yuko
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317889/
https://ncbi.nlm.nih.gov/pubmed/24698107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12410
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