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Japanese phase I study of GC33, a humanized antibody against glypican-3 for advanced hepatocellular carcinoma

GC33 is a humanized mAb against human glypican-3 (GPC3). In the first-in-human study carried out in the USA, GC33 was well tolerated and showed preliminary antitumor activity in patients with advanced hepatocellular carcinoma. This study aimed to assess the safety, tolerability, and pharmacokinetic...

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Bibliografske podrobnosti
izdano v:Cancer Sci
Main Authors: Ikeda, Masafumi, Ohkawa, Shinichi, Okusaka, Takuji, Mitsunaga, Shuichi, Kobayashi, Satoshi, Morizane, Chigusa, Suzuki, Ikue, Yamamoto, Shunsuke, Furuse, Junji
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317809/
https://ncbi.nlm.nih.gov/pubmed/24521523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12368
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