New loci and coding variants confer risk for age-related macular degeneration in East Asians

Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 c...

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Published in:Nat Commun
Main Authors: Cheng, Ching-Yu, Yamashiro, Kenji, Jia Chen, Li, Ahn, Jeeyun, Huang, Lulin, Huang, Lvzhen, Cheung, Chui Ming G., Miyake, Masahiro, Cackett, Peter D., Yeo, Ian Y., Laude, Augustinus, Mathur, Ranjana, Pang, Junxiong, Sim, Kar Seng, Koh, Adrian H., Chen, Peng, Lee, Shu Yen, Wong, Doric, Chan, Choi Mun, Loh, Boon Kwang, Sun, Yaoyao, Davila, Sonia, Nakata, Isao, Nakanishi, Hideo, Akagi-Kurashige, Yumiko, Gotoh, Norimoto, Tsujikawa, Akitaka, Matsuda, Fumihiko, Mori, Keisuke, Yoneya, Shin, Sakurada, Yoichi, Iijima, Hiroyuki, Iida, Tomohiro, Honda, Shigeru, Lai, Timothy Yuk Yau, Tam, Pancy Oi Sin, Chen, Haoyu, Tang, Shibo, Ding, Xiaoyan, Wen, Feng, Lu, Fang, Zhang, Xiongze, Shi, Yi, Zhao, Peiquan, Zhao, Bowen, Sang, Jinghong, Gong, Bo, Dorajoo, Rajkumar, Yuan, Jian-Min, Koh, Woon-Puay, van Dam, Rob M., Friedlander, Yechiel, Lin, Ying, Hibberd, Martin L., Foo, Jia Nee, Wang, Ningli, Wong, Chang Hua, Tan, Gavin S., Park, Sang Jun, Bhargava, Mayuri, Gopal, Lingam, Naing, Thet, Liao, Jiemin, Guan Ong, Peng, Mitchell, Paul, Zhou, Peng, Xie, Xuefeng, Liang, Jinlong, Mei, Junpu, Jin, Xin, Saw, Seang-Mei, Ozaki, Mineo, Mizoguchi, Takanori, Kurimoto, Yasuo, Woo, Se Joon, Chung, Hum, Yu, Hyeong-Gon, Shin, Joo Young, Park, Dong Ho, Kim, In Taek, Chang, Woohyok, Sagong, Min, Lee, Sang-Joon, Kim, Hyun Woong, Lee, Ji Eun, Li, Yi, Liu, Jianjun, Teo, Yik Ying, Heng, Chew Kiat, Lim, Tock Han, Yang, Suk-Kyun, Song, Kyuyoung, Vithana, Eranga N., Aung, Tin, Bei, Jin Xin, Zeng, Yi Xin, Tai, E. Shyong, Li, Xiao Xin, Yang, Zhenglin, Park, Kyu-Hyung, Pang, Chi Pui, Yoshimura, Nagahisa, Yin Wong, Tien, Khor, Chiea Chuen
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317498/
https://ncbi.nlm.nih.gov/pubmed/25629512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7063
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