Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells

Increases in prostaglandin E(2) (PGE(2)) and cyclooxygenase-2 (COX-2) levels are features of colon cancer. Among the different E-type prostanoid receptor subtypes, EP4 receptors are considered to play a crucial role in carcinogenesis by, for example, inducing COX-2 when stimulated with PGE(2). Howev...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Otake, Sho, Yoshida, Kenji, Seira, Naofumi, Sanchez, Christopher M, Regan, John W, Fujino, Hiromichi, Murayama, Toshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317221/
https://ncbi.nlm.nih.gov/pubmed/25692008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.83
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