HTRA1 (High Temperature Requirement A Serine Peptidase 1) Gene Is Transcriptionally Regulated by Insertion/Deletion Nucleotides Located at the 3′ End of the ARMS2 (Age-related Maculopathy Susceptibility 2) Gene in Patients with Age-related Macular Degeneration

Dry age-related macular degeneration (AMD) accounts for over 85% of AMD cases in the United States, whereas Japanese AMD patients predominantly progress to wet AMD or polypoidal choroidal vasculopathy. Recent genome-wide association studies have revealed a strong association between AMD and an inser...

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Vydáno v:J Biol Chem
Hlavní autoři: Iejima, Daisuke, Itabashi, Takeshi, Kawamura, Yuich, Noda, Toru, Yuasa, Shinsuke, Fukuda, Keiichi, Oka, Chio, Iwata, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317043/
https://ncbi.nlm.nih.gov/pubmed/25519903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593384
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