Phosphorylation of Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) by Akt Promotes Stability and Mitogenic Function of S-phase Kinase-associated Protein-2 (Skp2)

The regulation of the cell cycle by the ubiquitin-proteasome system is dependent on the activity of E3 ligases. Skp2 (S-phase kinase associated protein-2) is the substrate recognition subunit of the E3 ligase that ubiquitylates the cell cycle inhibitors p21(cip1) and p27(kip1) thus promoting cell cy...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Song, Gyun Jee, Leslie, Kristen L., Barrick, Stacey, Mamonova, Tatyana, Fitzpatrick, Jeremy M., Drombosky, Kenneth W., Peyser, Noah, Wang, Bin, Pellegrini, Maria, Bauer, Philip M., Friedman, Peter A., Mierke, Dale F., Bisello, Alessandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317011/
https://ncbi.nlm.nih.gov/pubmed/25492869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609768
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