Phosphorylation of Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) by Akt Promotes Stability and Mitogenic Function of S-phase Kinase-associated Protein-2 (Skp2)

The regulation of the cell cycle by the ubiquitin-proteasome system is dependent on the activity of E3 ligases. Skp2 (S-phase kinase associated protein-2) is the substrate recognition subunit of the E3 ligase that ubiquitylates the cell cycle inhibitors p21(cip1) and p27(kip1) thus promoting cell cy...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Song, Gyun Jee, Leslie, Kristen L., Barrick, Stacey, Mamonova, Tatyana, Fitzpatrick, Jeremy M., Drombosky, Kenneth W., Peyser, Noah, Wang, Bin, Pellegrini, Maria, Bauer, Philip M., Friedman, Peter A., Mierke, Dale F., Bisello, Alessandro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317011/
https://ncbi.nlm.nih.gov/pubmed/25492869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609768
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