Phosphorylation of Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) by Akt Promotes Stability and Mitogenic Function of S-phase Kinase-associated Protein-2 (Skp2)

The regulation of the cell cycle by the ubiquitin-proteasome system is dependent on the activity of E3 ligases. Skp2 (S-phase kinase associated protein-2) is the substrate recognition subunit of the E3 ligase that ubiquitylates the cell cycle inhibitors p21(cip1) and p27(kip1) thus promoting cell cy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Song, Gyun Jee, Leslie, Kristen L., Barrick, Stacey, Mamonova, Tatyana, Fitzpatrick, Jeremy M., Drombosky, Kenneth W., Peyser, Noah, Wang, Bin, Pellegrini, Maria, Bauer, Philip M., Friedman, Peter A., Mierke, Dale F., Bisello, Alessandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317011/
https://ncbi.nlm.nih.gov/pubmed/25492869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609768
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