Fancd2 Is Required for Nuclear Retention of Foxo3a in Hematopoietic Stem Cell Maintenance

Functional maintenance of hematopoietic stem cells (HSCs) is constantly challenged by stresses like DNA damage and oxidative stress. Here we show that the Fanconi anemia protein Fancd2 and stress transcriptional factor Foxo3a cooperate to prevent HSC exhaustion in mice. Deletion of both Fancd2 and F...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Li, Xiaoli, Li, Jie, Wilson, Andrew, Sipple, Jared, Schick, Jonathan, Pang, Qishen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317007/
https://ncbi.nlm.nih.gov/pubmed/25505262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619536
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