Association of osteoprotegerin and bone loss after adjuvant chemotherapy in early-stage breast cancer

PURPOSE: Chemotherapy induced ovarian failure (CIOF) results in rapid bone loss. Receptor Activator of Nuclear Factor Kappa-B (RANK)-RANK ligand (RANK-L) signaling balances bone resorption and formation. Osteoprotegerin (OPG) acts as a decoy receptor for RANK, interrupting osteoclast activation and...

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Publicado en:Mol Cell Endocrinol
Main Authors: Oostra, Drew R., Lustberg, Maryam B., Reinbolt, Raquel E., Pan, Xueliang, Wesolowski, Robert, Shapiro, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316829/
https://ncbi.nlm.nih.gov/pubmed/25575458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2014.12.028
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