Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation. Angiopoietin-2 (Ang2) functions as a context-dependent Tie2 agonist/antagonist promoting pathological angiogenesis, vascular pe...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Hakanpaa, Laura, Sipila, Tuomas, Leppanen, Veli-Matti, Gautam, Prson, Nurmi, Harri, Jacquemet, Guillaume, Eklund, Lauri, Ivaska, Johanna, Alitalo, Kari, Saharinen, Pipsa
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316742/
https://ncbi.nlm.nih.gov/pubmed/25635707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6962
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items