Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation. Angiopoietin-2 (Ang2) functions as a context-dependent Tie2 agonist/antagonist promoting pathological angiogenesis, vascular pe...

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Udgivet i:Nat Commun
Main Authors: Hakanpaa, Laura, Sipila, Tuomas, Leppanen, Veli-Matti, Gautam, Prson, Nurmi, Harri, Jacquemet, Guillaume, Eklund, Lauri, Ivaska, Johanna, Alitalo, Kari, Saharinen, Pipsa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316742/
https://ncbi.nlm.nih.gov/pubmed/25635707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6962
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