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Impacts of Activation of the Mitogen-Activated Protein Kinase Pathway in Pancreatic Cancer
Pancreatic cancer is characterized by constitutive activation of the mitogen-activated protein kinase (MAPK) pathway. Mutations of KRAS or BRAF and epigenetic abrogation of DUSP6 contribute synergistically to the constitutive activation of MAPK. Active MAPK induces the expression of a variety of gen...
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| Publicado no: | Front Oncol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4316689/ https://ncbi.nlm.nih.gov/pubmed/25699241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00023 |
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