The IL-10 polarized cytokine pattern in innate and adaptive immunity cells contribute to the development of FVIII inhibitors

BACKGROUND: Hemophilia A (HA) is an X-linked inherited bleeding disorder, resulting from a qualitative or quantitative deficiency of clotting factor VIII (FVIII). Antibodies against FVIII, also called inhibitors, block the procoagulant activity of FVIII; thus, impairing hemostatic activity in patien...

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Vydáno v:BMC Hematol
Hlavní autoři: Silveira, Amanda CO, Santana, Marcio AP, Ribeiro, Isabella G, Chaves, Daniel G, Martins-Filho, Olindo A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316397/
https://ncbi.nlm.nih.gov/pubmed/25653866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12878-014-0019-8
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