Enzyme replacement therapy in Gaucher's disease: large-scale purification of glucocerebrosidase suitable for human administration.

Enzyme replacement therapy for the alleviation of Gaucher's disease has been impeded because of the difficulty in preparing large amounts of glucocerebrosidase, the enzyme that is deficient in patients with this disorder. A large-scale procedure for the purification of human placental glucocerebrosi...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Furbish, F S, Blair, H E, Shiloach, J, Pentchev, P G, Brady, R O
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1977
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431631/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/269414/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.8.3560
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