Optogenetic Stimulation of Adrenergic C1 Neurons Causes Sleep State–Dependent Cardiorespiratory Stimulation and Arousal with Sighs in Rats

Rationale: The rostral ventrolateral medulla (RVLM) contains central respiratory chemoreceptors (retrotrapezoid nucleus, RTN) and the sympathoexcitatory, hypoxia-responsive C1 neurons. Simultaneous optogenetic stimulation of these neurons produces vigorous cardiorespiratory stimulation, sighing, and...

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Detalles Bibliográficos
Publicado en:Am J Respir Crit Care Med
Main Authors: Burke, Peter G. R., Abbott, Stephen B. G., Coates, Melissa B., Viar, Kenneth E., Stornetta, Ruth L., Guyenet, Patrice G.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315817/
https://ncbi.nlm.nih.gov/pubmed/25325789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201407-1262OC
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