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Host miR-155 promotes tumor growth through a myeloid-derived suppressor cell-dependent mechanism

miR-155 is a regulator of immune cell development and function that is generally thought to be immunostimulatory. However, we report here that genetic ablation of miR-155 renders mice resistant to chemical carcinogenesis and the growth of several transplanted tumors, suggesting that miR-155 function...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Chen, Siqi, Wang, Long, Fan, Jie, Ye, Cong, Dominguez, Donye, Zhang, Yi, Curiel, Tyler J., Fang, Deyu, Kuzel, Timothy M., Zhang, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315710/
https://ncbi.nlm.nih.gov/pubmed/25502838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2331
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