Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

Nitric oxide gas (NO) increased guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] activity in soluble and particulate preparations from various tissues. The effect was dose-dependent and was observed with all tissue preparations examined. The extent of activation was variable among...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Arnold, William P., Mittal, Chandra K., Katsuki, Shoji, Murad, Ferid
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1977
Schlagworte:	Biological Sciences: Biochemistry
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/20623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.8.3203
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