Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer’s disease

BACKGROUND: In Alzheimer’s disease synapse loss precedes neuronal loss and correlates best with impaired memory formation. However, the mechanisms underlying synaptic degeneration in Alzheimer’s disease are not well known. Further, it is unclear why synapses in AD cerebellum are protected from degen...

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Publicado en:Mol Brain
Main Authors: Tiwari, Sachin S, d’Orange, Marie, Troakes, Claire, Shurovi, Badrun N, Engmann, Olivia, Noble, Wendy, Hortobágyi, Tibor, Giese, Karl P
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314762/
https://ncbi.nlm.nih.gov/pubmed/25631211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-015-0096-z
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