Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet

OBJECTIVE: Elevated serum levels of the lymphangiogenic factors VEGF-C and -D have been observed in obese individuals but their relevance for the metabolic syndrome has remained unknown. METHODS: K14–VEGFR-3–Ig (sR3) mice that constitutively express soluble-VEGFR-3–Ig in the skin, scavenging VEGF-C...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Karaman, Sinem, Hollmén, Maija, Robciuc, Marius R., Alitalo, Annamari, Nurmi, Harri, Morf, Bettina, Buschle, Dorina, Alkan, H. Furkan, Ochsenbein, Alexandra M., Alitalo, Kari, Wolfrum, Christian, Detmar, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314545/
https://ncbi.nlm.nih.gov/pubmed/25685697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.11.006
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