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IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells

It was reported that TNF receptor type II signaling, which has the capacity to stimulate CD4(+) forkhead box P3(+) (Foxp3(+)) regulatory T cells (Tregs), activated the noncanonical NF-κB pathway in an IKKα-dependent manner. Therefore, we studied the role of IKKα in the homeostasis of Treg population...

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Publicat a:FASEB J
Autors principals: Chen, Xin, Willette-Brown, Jami, Wu, Xueqiang, Hu, Ya, Howard, O. M. Zack, Hu, Yinling, Oppenheim, Joost J.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314223/
https://ncbi.nlm.nih.gov/pubmed/25376833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-259564
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