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Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease
Chromosome fragmentation is a hallmark of apoptosis, conserved in diverse organisms. In mammals, caspases activate apoptotic chromosome fragmentation by cleaving and inactivating an apoptotic nuclease inhibitor. We report that inactivation of the C. elegans dcr-1 gene, which encodes the Dicer ribonu...
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| Publicado no: | Science |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4313557/ https://ncbi.nlm.nih.gov/pubmed/20223951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1182374 |
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