Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats

Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induce...

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Udgivet i:J Mol Cell Cardiol
Main Authors: Escobales, Nelson, Nuñez, Rebeca E., Jang, Sehwan, Parodi-Rullan, Rebecca, Ayala-Peña, Sylvette, Sacher, Joshua R., Skoda, Erin M., Wipf, Peter, Frontera, Walter, Javadov, Sabzali
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312194/
https://ncbi.nlm.nih.gov/pubmed/25451170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.10.009
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