Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis while M2 macrophages promote vessel maturation. Therefore, we reasoned that scaffolds th...

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Publicado en:Biomaterials
Main Authors: Spiller, Kara L., Nassiri, Sina, Witherel, Claire E., Anfang, Rachel R., Ng, Johnathan, Nakazawa, Kenneth R., Yu, Tony, Vunjak-Novakovic, Gordana
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312192/
https://ncbi.nlm.nih.gov/pubmed/25453950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.10.017
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