Sequence specificity of mutagen-nucleic acid complexes in solution: Intercalation and mutagen-base pair overlap geometries for proflavine binding to dC-dC-dG-dG and dG-dG-dC-dC self-complementary duplexes

The complex formed between the mutagen proflavine and the dC-dC-dG-dG and dG-dG-dC-dC self-complementary tetranucleotide duplexes has been monitored by proton high resolution nuclear magnetic resonance spectroscopy in 0.1 M phosphate solution at high nucleotide/drug ratios. The large upfield shifts...

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Bibliographic Details
Main Authors: Patel, Dinshaw J., Canuel, Lita L.
Format: Artigo
Language:Inglês
Published: 1977
Subjects:
Physical Sciences: Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC431217/
https://ncbi.nlm.nih.gov/pubmed/268613
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