Phenylalanine in the Pore of the Erwinia Ligand-Gated Ion Channel Modulates Picrotoxinin Potency but Not Receptor Function

[Image: see text] The Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of eukaryotic Cys-loop ligand-gated ion channels. This protein has the potential to be a useful model for Cys-loop receptors but is unusual in that it has an aromatic residue (Phe) facing into the pore, leading to...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Thompson, Andrew J., Alqazzaz, Mona, Price, Kerry L., Weston, David A., Lummis, Sarah C. R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312132/
https://ncbi.nlm.nih.gov/pubmed/25238029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5008035
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