Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome

Gilles de la Tourette syndrome (TS) is characterized by tics, which are transiently worsened by stress, acute administration of dopaminergic drugs, and by subtle deficits in motor coordination and sensorimotor gating. It represents the most severe end of a spectrum of tic disorders that, in aggregat...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xu, Meiyu, Kobets, Andrew, Du, Jung-Chieh, Lennington, Jessica, Li, Lina, Banasr, Mounira, Duman, Ronald S., Vaccarino, Flora M., DiLeone, Ralph J., Pittenger, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311862/
https://ncbi.nlm.nih.gov/pubmed/25561540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419533112
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