Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2

Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin–angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1–7. This conversion inactivates the vasoconstrictive...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Clayton, Daniel, Hanchapola, Iresha, Thomas, Walter G., Widdop, Robert E., Smith, Alexander I., Perlmutter, Patrick, Aguilar, Marie-Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311625/
https://ncbi.nlm.nih.gov/pubmed/25688208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00005
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