G3139 (Genasense) in Patients With Advanced Merkel Cell Carcinoma

OBJECTIVES: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy of the skin. Preclinical studies have identified up-regulation of the critical antiapoptosis gene bcl-2 in MCC. We conducted a multicenter phase II trial of the novel bcl-2 antisense agent (G3139, Genasense) in p...

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Udgivet i:Am J Clin Oncol
Main Authors: Shah, Manisha H., Varker, Kimberly A., Collamore, Minden, Zwiebel, James A., Coit, Daniel, Kelsen, David, Chung, Ki Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311264/
https://ncbi.nlm.nih.gov/pubmed/19307957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COC.0b013e31817eebf8
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