Identification of a Major Epitope Recognized by PLA2R Autoantibodies in Primary Membranous Nephropathy

Phospholipase A(2) receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized by 90% of human anti-PLA2R autoantibodies. The epitope was sen...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Fresquet, Maryline, Jowitt, Thomas A., Gummadova, Jennet, Collins, Richard, O’Cualain, Ronan, McKenzie, Edward A., Lennon, Rachel, Brenchley, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2015
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310666/
https://ncbi.nlm.nih.gov/pubmed/25288605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014050502
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