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The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis
Hedgehog (Hh) is a developmental signaling pathway in which Hh ligands bind Patched (Ptch), which relieves its inhibition of Smoothened (Smo), allowing the Gli family of transcription factors to translocate to the nucleus and activate Hh target genes. The role of Hh signaling in hematopoiesis is con...
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| 發表在: | Leukemia |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4310480/ https://ncbi.nlm.nih.gov/pubmed/21660044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.143 |
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