Development of intramammary delivery systems containing lasalocid for the treatment of bovine mastitis: impact of solubility improvement on safety, efficacy, and milk distribution in dairy cattle

BACKGROUND: Mastitis is a major disease of dairy cattle. Given the recent emergence of methicillin-resistant Staphylococcus aureus as a cause of bovine mastitis, new intramammary (IMA) treatments are urgently required. Lasalocid, a member of the polyether ionophore class of antimicrobial agents, has...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Wang, Wen, Song, Yunmei, Petrovski, Kiro, Eats, Patricia, Trott, Darren J, Wong, Hui San, Page, Stephen W, Perry, Jeanette, Garg, Sanjay
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2015
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310348/
https://ncbi.nlm.nih.gov/pubmed/25653501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S74731
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