Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols.

The trace metals nickel and platinum, which are not substrates for ferrochelatase and thus do not form heme in biological systems, were found to act similaryl to cobalt, and heme itself, in regulating heme metabolism in liver and kidney. These metals induced heme oxygenase activity in both organs wi...

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Bibliographic Details
Main Authors: Maines, M D, Kappas, A
Format: Artigo
Language:Inglês
Published: 1977
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC431034/
https://ncbi.nlm.nih.gov/pubmed/266710
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