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Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells

High glucose and fatty acid levels impair pancreatic beta cell function. We have recently shown that palmitate-induced loss of INS-1E insulinoma cells is related to increased reactive oxygen species (ROS) production as both toxic effects are prevented by palmitoleate. Here we show that palmitate-ind...

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Bibliografske podrobnosti
izdano v:Redox Biol
Main Authors: Barlow, Jonathan, Hirschberg Jensen, Verena, Affourtit, Charles
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309862/
https://ncbi.nlm.nih.gov/pubmed/25482405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2014.11.009
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