Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis. The role of nSMase2 in apoptosis is debated, and apparently contradictory results have been observed on fibroblasts isolate...

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Detalhes bibliográficos
Publicado no:Redox Biol
Principais autores: Garoby-Salom, Sandra, Rouahi, Myriam, Mucher, Elodie, Auge, Nathalie, Salvayre, Robert, Negre-Salvayre, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309855/
https://ncbi.nlm.nih.gov/pubmed/25555205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2014.12.004
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