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Proton pump inhibitors do not impair the effectiveness of metformin in patients with diabetes

AIMS: In order to exert its pharmacodynamic effect, the diabetes drug metformin needs to be taken up into hepatocytes by the organic cation transporter (OCT) system. A recent in vitro study found that proton pump inhibitors (PPIs) inhibit OCT1, OCT2 and OCT3, suggesting that PPIs might reduce metfor...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Flory, James, Haynes, Kevin, Leonard, Charles E, Hennessy, Sean
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309638/
https://ncbi.nlm.nih.gov/pubmed/25199921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12506
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