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Proton pump inhibitors do not impair the effectiveness of metformin in patients with diabetes
AIMS: In order to exert its pharmacodynamic effect, the diabetes drug metformin needs to be taken up into hepatocytes by the organic cation transporter (OCT) system. A recent in vitro study found that proton pump inhibitors (PPIs) inhibit OCT1, OCT2 and OCT3, suggesting that PPIs might reduce metfor...
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| Publicado en: | Br J Clin Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4309638/ https://ncbi.nlm.nih.gov/pubmed/25199921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12506 |
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