TSH Signaling Overcomes B-RafV600E–Induced Senescence in Papillary Thyroid Carcinogenesis through Regulation of DUSP6()()

B-RafV600E oncogene mutation occurs most commonly in papillary thyroid carcinoma (PTC) and is associated with tumor initiation. However, a genetic modification by B-RafV600E in thyrocytes results in oncogene-induced senescence (OIS). In the present study, we explored the factors involved in the sene...

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Udgivet i:Neoplasia
Main Authors: Kim, Young Hwa, Choi, Yong Won, Han, Jae Ho, Lee, Jeonghun, Soh, Euy Young, Park, So Hyun, Kim, Jang-Hee, Park, Tae Jun
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309262/
https://ncbi.nlm.nih.gov/pubmed/25499223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.10.005
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