Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure

Loss of sensory hair cells from exposure to certain licit drugs (e.g., aminoglycoside antibiotics, platinum-based chemotherapy agents) can result in permanent hearing loss. Here we ask if allosteric activation of the hepatocyte growth factor (HGF) cascade via Dihexa, a small molecule drug candidate,...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Uribe, Phillip M., Kawas, Leen H., Harding, Joseph W., Coffin, Allison B.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309183/
https://ncbi.nlm.nih.gov/pubmed/25674052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00003
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