Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts

L-type voltage-sensitive calcium channels (LTCCs), particularly Cav1.2 LTCCs, play fundamental roles in cellular responses to mechanical stimuli in osteoblasts. Numerous studies have shown that mechanical loading promotes bone formation, whereas the removal of this stimulus under microgravity condit...

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Publicat a:Sci Rep
Autors principals: Sun, Zhongyang, Cao, Xinsheng, Zhang, Zhuo, Hu, Zebing, Zhang, Lianchang, Wang, Han, Zhou, Hua, Li, Dongtao, Zhang, Shu, Xie, Manjiang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4308706/
https://ncbi.nlm.nih.gov/pubmed/25627864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08077
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