Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles

Many powerful drugs have limited clinical utility because of poor water solubility and high systemic toxicity. Here, we formulated a targeted nanomedicine, rapamycin encapsulated in pegylated octadecyl lithocholate micelles labeled with a new ligand for colorectal neoplasia, LTTHYKL peptide. CPC;Apc...

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Veröffentlicht in:J Control Release
Hauptverfasser: Khondee, Supang, Rabinsky, Emily F., Owens, Scott R., Joshi, Bishnu P., Qiu, Zhen, Duan, Xiyu, Zhao, Lili, Wang, Thomas D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4308466/
https://ncbi.nlm.nih.gov/pubmed/25483425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.11.034
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