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Connexin 43 Suppresses Tumor Angiogenesis by Down-Regulation of Vascular Endothelial Growth Factor via Hypoxic-Induced Factor-1α

Previous work showed that connexin 43 (Cx43) reduced the expression of hypoxic-induced factor-1α (HIF-1α) in astrocytes. HIF-1α is a master transcription factor for angiogenesis in tumor. Angiogenesis is essential for tumor progression. Here, we investigated the role of Cx43 in vascular endothelial...

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Bibliografische gegevens
Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Wang, Wei-Kuang, Chen, Man-Chin, Leong, Hon-Fai, Kuo, Yu-Liang, Kuo, Chun-Yu, Lee, Che-Hsin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307255/
https://ncbi.nlm.nih.gov/pubmed/25548899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms16010439
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