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Biosynthesis of Akaeolide and Lorneic Acids and Annotation of Type I Polyketide Synthase Gene Clusters in the Genome of Streptomyces sp. NPS554

The incorporation pattern of biosynthetic precursors into two structurally unique polyketides, akaeolide and lorneic acid A, was elucidated by feeding experiments with (13)C-labeled precursors. In addition, the draft genome sequence of the producer, Streptomyces sp. NPS554, was performed and the bio...

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Bibliografski detalji
Izdano u:Mar Drugs
Glavni autori: Zhou, Tao, Komaki, Hisayuki, Ichikawa, Natsuko, Hosoyama, Akira, Sato, Seizo, Igarashi, Yasuhiro
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2015
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306953/
https://ncbi.nlm.nih.gov/pubmed/25603349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13010581
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