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Gating pore currents are defects in common with two Na(v)1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy

The gating pore current, also called omega current, consists of a cation leak through the typically nonconductive voltage-sensor domain (VSD) of voltage-gated ion channels. Although the study of gating pore currents has refined our knowledge of the structure and the function of voltage-gated ion cha...

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Bibliografski detalji
Izdano u:J Gen Physiol
Glavni autori: Moreau, Adrien, Gosselin-Badaroudine, Pascal, Delemotte, Lucie, Klein, Michael L., Chahine, Mohamed
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306709/
https://ncbi.nlm.nih.gov/pubmed/25624448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411304
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