Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function

BACKGROUND: Circulating angiotensin II (AngII) is elevated in congestive heart failure (CHF), and leads to skeletal muscle wasting, which is strongly associated with poor patient outcomes. We previously found that AngII upregulates protein phosphatase 2C-alpha (PP2Cα) and dephosphorylates AMP-activa...

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Bibliographic Details
Published in:	Skelet Muscle
Main Authors:	Tabony, Alexander Michael, Yoshida, Tadashi, Sukhanov, Sergiy, Delafontaine, Patrice
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2014
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4306116/ https://ncbi.nlm.nih.gov/pubmed/25625009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-4-20
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Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function

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