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Effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat

AIM: Retention and accumulation of toxic hydrophobic bile salts within hepatocyte may cause hepatocyte toxicity by inducing apoptosis. Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Z-Val-Ala-Asp (OMe)-fluoromethyl ketone (ZVAD-fmk) is a cell-permeable ir...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Sheen-Chen, Shyr-Ming, Ho, Hsin-Tsung, Chen, Wei-Jen, Eng, Hock-Liew
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305820/
https://ncbi.nlm.nih.gov/pubmed/15818747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i15.2330
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